Related Experiment Video
Updated: Jan 20, 2026
11:53
Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
Published on: July 21, 2017
7.7K
PEGylation of shellac-based nanocarriers for enhanced colloidal stability
Mongkhol Prawatborisut1, Farzad Seidi1, Doungporn Yiamsawas2
1Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong, 21210, Thailand.
Colloids and Surfaces. B, Biointerfaces
|August 23, 2019
Summary
Shellac nanoparticles effectively encapsulate corrosion inhibitors. PEGylation enhances stability in saline conditions while maintaining controlled release kinetics for 2-mercaptobenzothiazole.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Corrosion Inhibition
Background:
- Shellac, a natural resin from lac insects, is a promising biomaterial for nanoparticle development.
- Encapsulating corrosion inhibitors within nanoparticles offers controlled delivery and enhanced protection.
- Shellac nanoparticles exhibit potential for delivering active compounds like 2-mercaptobenzothiazole.
Purpose of the Study:
- To develop and characterize shellac-based nanoparticles for encapsulating the corrosion inhibitor 2-mercaptobenzothiazole.
- To investigate the release kinetics of the inhibitor influenced by pH and co-polymers.
- To improve the colloidal stability of shellac nanoparticles in saline environments via PEGylation.
Main Methods:
- Nanoparticle preparation using nanoprecipitation and miniemulsion techniques.
- Encapsulation efficiency assessment of 2-mercaptobenzothiazole.
- In vitro release studies under varying pH and in the presence of lignin and zein.
- Poly(ethylene glycol) (PEG) conjugation to shellac for enhanced stability.
Main Results:
- Efficient encapsulation of 2-mercaptobenzothiazole in shellac nanoparticles was achieved.
- Release kinetics were modulated by pH and the incorporation of biopolymers.
- PEGylation of shellac nanoparticles improved colloidal stability in saline conditions.
- PEGylated nanoparticles exhibited similar 2-mercaptobenzothiazole release profiles to unmodified ones.
Conclusions:
- Shellac-based nanoparticles are effective carriers for the corrosion inhibitor 2-mercaptobenzothiazole.
- Controlled release can be achieved by adjusting environmental factors and material composition.
- PEGylation offers a viable strategy to enhance the stability of shellac nanoparticles for practical applications.
Related Concept Videos
03:22Colloids
20.8K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
20.8K
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
200
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
200
01:53RNA Stability
35.6K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.6K
01:17Colloids and Suspensions
3.1K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
3.1K
01:09Colloidal precipitates
5.9K
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
5.9K
03:18Nuclear Stability
22.9K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
To hold positively charged protons together...
22.9K