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Updated: Jan 20, 2026

Electrophoretic Mobility Shift Assay EMSA for the Study of RNA-Protein Interactions: The IRE/IRP Example
Published on: December 3, 2014
Avoiding raising the ire of IRE1α
Luis B Agellon1, Marek Michalak2
1School of Human Nutrition, McGill University, Ste. Anne de Bellevue, Quebec, H9X 3V9, Canada.
Abstract:
IRE1α is well known as a regulator of one branch of the UPR pathway that is activated during ER stress that operates to regain ER proteostasis. In a recent paper, Carreras-Sureda et al. show that IRE1α is also a structural component of MAMs and facilitates the uptake of Ca2+ by mitochondria.
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