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Updated: Jan 20, 2026

A High-throughput Assay for the Prediction of Chemical Toxicity by Automated Phenotypic Profiling of Caenorhabditis elegans
Published on: March 14, 2019
Nanopolystyrene at predicted environmental concentration enhances microcystin-LR toxicity by inducing intestinal
Man Qu1, Akram Nida1, Yan Kong1
1Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School, Southeast University, Nanjing, 210009, China.
Abstract:
We employed nematode Caenorhabditis elegans to determine the combinational effect between nanopolystyrene at predicted environmental concentration and microcystin-LR (MC-LR). Prolonged exposure to nanopolystyrene (1 μg/L) increased MC-LR (0.1 μg/L) toxicity in reducing brood size and locomotion behavior and in inducing oxidative stress. Moreover, the adsorption of MC-LR by nanopolystyrene particles played an important role in inducing the enhancement in MC-LR toxicity by nanopolystyrene particles. Additionally, only exposure to resuspension of nanopolystyrene (1 μg/L) caused the increased intestinal permeability in MC-LR (0.1 μg/L) exposed nematodes. Our data indicates the potential of nanopolystyrene at predicted environmental concentration in enhancing MC-LR toxicity on environmental organisms.
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