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Finding Options Beyond Standard of Care in Oncology: A Proposal for Workflows Utilizing Knowledge Databases
Katrin Glocker1, Janko Ahlbrandt1, Alexander Knurr1
1Division of Medical Informatics for Translational Oncology, German Cancer Research Center (DKFZ), Heidelberg, Baden Württemberg, Germany.
Databases are crucial for molecularly stratified therapies, aiding Molecular Tumor Boards (MTB) in identifying targeted treatment options. This work lists relevant databases and workflows to standardize clinical curation for personalized cancer care.
Area of Science:
- Oncology
- Bioinformatics
- Genomics
Background:
- Molecularly stratified therapies require comprehensive data on tumor genetic characteristics.
- Molecular Tumor Boards (MTB) rely on external knowledge databases for therapeutic decision-making.
Purpose of the Study:
- To identify and present a curated list of databases relevant for clinical Molecular Tumor Boards (MTB).
- To describe workflows for integrating these databases into the clinical curation process.
Main Methods:
- Systematic review and evaluation of external knowledge databases for clinical relevance.
- Development of standardized workflows for database utilization in MTB settings.
Main Results:
- A comprehensive list of useful and relevant databases for MTB has been compiled.
- Workflows are proposed to guide the selection and use of databases at various stages of clinical curation.
Conclusions:
- Informed database selection is essential for evaluating molecular alterations and developing targeted therapies.
- Standardized use of relevant databases facilitates the effective functioning of Molecular Tumor Boards (MTB).
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