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Risk of Acute Myocardial Infarction in Patients with Rheumatic Arthritis: A National-Wide Population-Based Cohort

Md Mohaimenul Islam1,2, Taimina Nasrin Poly1,2, Hsuan-Chia Yang1,2

  • 1Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei, Taiwan.

Studies in Health Technology and Informatics
|August 24, 2019
PubMed

Insights

Rheumatic arthritis (RA) is linked to a higher risk of acute myocardial infarction (AMI). This study found that RA patients have a statistically significant increased risk for AMI, highlighting a crucial connection for cardiovascular health.

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Epidemiology

Background:

  • Rheumatic arthritis (RA) is a chronic autoimmune disease affecting joints.
  • Cardiovascular disease, including acute myocardial infarction (AMI), is a significant concern in RA patients.
  • Understanding the specific risks associated with RA is crucial for patient management.

Purpose of the Study:

  • To quantify the association between rheumatic arthritis (RA) and the risk of acute myocardial infarction (AMI).
  • To determine if RA confers an elevated risk for developing AMI.

Main Methods:

  • A cohort study design was employed.
  • International Classification of Diseases, 9th Revision (ICD-9) codes were used for patient identification.
  • Cox proportional hazards models, adjusted for confounding factors, were utilized to assess risk.

Main Results:

  • The study identified a cohort of patients with rheumatic arthritis and acute myocardial infarction.
  • An adjusted hazard ratio (aHR) of 1.05 (95% CI 1.01-1.09) indicated an increased risk of AMI in RA patients.
  • Rheumatic arthritis was found to be associated with a statistically significant increase in the risk of acute myocardial infarction.

Conclusions:

  • Rheumatic arthritis is associated with an elevated risk of acute myocardial infarction.
  • These findings underscore the importance of cardiovascular risk assessment and management in individuals with RA.
  • Further research may explore underlying mechanisms linking RA and AMI.

Keywords:
Acute Myocardial InfarctionCohort StudiesRheumatic Arthritis

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