Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacovigilance01:19

Pharmacovigilance

1.6K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.6K
Base Excision Repair01:54

Base Excision Repair

26.1K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.1K
Lewis Acids and Bases02:33

Lewis Acids and Bases

48.2K
In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
48.2K
DNA Base Pairing02:27

DNA Base Pairing

33.0K
Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
33.0K
Weak Base Solutions03:21

Weak Base Solutions

24.8K
Some compounds produce hydroxide ions when dissolved by chemically reacting with water molecules. In all cases, these compounds react only partially and so are classified as weak bases. These types of compounds are also abundant in nature and important commodities in various technologies. For example, global production of the weak base ammonia is typically well over 100 metric tons annually, being widely used as an agricultural fertilizer, a raw material for chemical synthesis of other...
24.8K
Ions as Acids and Bases02:54

Ions as Acids and Bases

26.2K
Salts with Acidic Ions
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
26.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prenatal exposure to Antiseizure Medications for all indications and the risk of neurodevelopmental disorders in offspring: a nationwide population-based cohort study in South Korea.

Seizure·2026
Same author

A Practical Approach to Assessing the Completeness of Electronic Health Records for Medical Research: Data Quality Study.

JMIR medical informatics·2026
Same author

A Practical Approach to Assessing the Completeness of Electronic Health Records for Medical Research: A Data Quality Study.

JMIR medical informatics·2026
Same author

Angiotensin Receptor Blockers and the Risk of Suspected Drug-Induced Liver Injury: A Retrospective Cohort Study Using Electronic Health Record-Based Common Data Model in South Korea.

Drug safety·2024
Same author

Prevalence and Clinical Characteristics of Mitochondrial DNA Mutations in Korean Patients With Sensorineural Hearing Loss.

Journal of Korean medical science·2023
Same author

Aneurysm and Artery Dissection After Oral VEGFR-TKI Use in Adults With Cancer.

JAMA network open·2023

Related Experiment Video

Updated: Jan 20, 2026

Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

8.0K

Korean Pharmacovigilance System Based on EHR-CDM.

Nayeong Son1, Bonggi Kim1, Sooyoun Chung1

  • 1Korea Institute of Drug Safety & Risk Management, Anyang-si, Gyeonggi-do 14051.

Studies in Health Technology and Informatics
|August 24, 2019
PubMed
Summary

Electronic health records (EHRs) are challenging for pharmacovigilance. A new common data model (CDM) and network (MOA-Net) were developed, proving effective for drug safety studies using millions of patient records.

Keywords:
Electronic health recordpharmacoepidemiologypharmacovigilance

More Related Videos

Executing Complexity-Increasing Queries in Relational MySQL and NoSQL MongoDB and EXist Size-Growing ISO/EN 13606 Standardized EHR Databases
07:26

Executing Complexity-Increasing Queries in Relational MySQL and NoSQL MongoDB and EXist Size-Growing ISO/EN 13606 Standardized EHR Databases

Published on: March 19, 2018

9.7K
Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates
08:32

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates

Published on: October 25, 2018

9.5K

Related Experiment Videos

Last Updated: Jan 20, 2026

Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

8.0K
Executing Complexity-Increasing Queries in Relational MySQL and NoSQL MongoDB and EXist Size-Growing ISO/EN 13606 Standardized EHR Databases
07:26

Executing Complexity-Increasing Queries in Relational MySQL and NoSQL MongoDB and EXist Size-Growing ISO/EN 13606 Standardized EHR Databases

Published on: March 19, 2018

9.7K
Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates
08:32

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates

Published on: October 25, 2018

9.5K

Area of Science:

  • Pharmacovigilance and Health Informatics
  • Drug Safety Research
  • Clinical Data Management

Background:

  • Electronic health records (EHRs) contain valuable clinical data but are difficult to utilize for pharmacovigilance.
  • Standardizing EHR data is crucial for large-scale drug safety studies.

Purpose of the Study:

  • To develop a common data model (CDM) for EHRs to facilitate pharmacovigilance.
  • To establish a network (MOA-Net) for data sharing and collaborative drug safety research.

Main Methods:

  • Converted EHRs from over 9 million patients into the MOA common data model (CDM) between 2016 and 2018.
  • Developed the MOA-Net web portal to connect CDM data partners.
  • Hospitals participated in pharmacovigilance studies using the MOA-Net platform.

Main Results:

  • Successfully converted a large volume of patient EHR data into a standardized CDM.
  • Established a functional network (MOA-Net) enabling collaborative research.
  • Demonstrated the usability and adequacy of the CDM for pharmacovigilance studies.

Conclusions:

  • The MOA common data model and MOA-Net provide a viable solution for leveraging EHR data in pharmacovigilance.
  • Standardized EHR data through CDM enhances the efficiency and scope of drug safety research.
  • The developed network facilitates collaboration among healthcare institutions for drug safety surveillance.