Value of normalized apparent diffusion coefficients in differentiating between borderline and malignant epithelial...

To compare the diagnostic performance of normalized apparent diffusion coefficients (nADCs) of different references with that of ADCs at differentb factors in differentiating borderline epithelial ovarian tumors (BEOTs) from malignant epithelial ovarian tumors (MEOTs).

This retrospective study included 53 BEOTs and 148 MEOTs. Conventional magnetic resonance and diffusion-weighted imaging withb factors of 800 and 1000s/mm² were performed. ADC was measured three times at solid components of tumors, gluteus maximus muscle (GMM), iliopsoas muscle (IM) and urine and then averaged. ADC_tumor, nADCs were then obtained. Differences and the diagnostic performance of ADC_tumor and nADCs between BEOTs and MEOTs with different b factors were compared.

ADC_tumor, nADCs regardless of b factors were significantly higher in BEOTs than MEOTs. The diagnostic performance of nADC_urine regardless of b factors was significantly larger than that of nADC_GMM and nADC_IM. There was no significant difference in the diagnostic performance between ADC_tumor and nADC_urine regardless of b factors. A significantly lower ADC_tumor and a larger diagnostic performance for ADC_tumor was found with a b factor of 1000s/mm² than 800 s/mm². There were no significant differences in nADC_urine of BEOTs or MEOTs or in the diagnostic performance of nADC_urine with b factors between 800 and 1000s/mm².

ADC_tumor and nADCs were both capable of differentiating BEOTs from MEOTs. nADC_urine was the best of all nADCs and was superior to ADC_tumor because of its stable performance in differentiating BEOTs from MEOTs, regardless of b factors.