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Updated: Jan 20, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
A positive emotion regulation intervention for bipolar I disorder: Treatment development and initial outcomes
Janelle M Painter1, Jasmine Mote1, Andrew D Peckham1
1University of California, Berkeley, Department of Psychology, United States of America.
Objective:
Dysfunction in positive affect is a defining symptom of bipolar I disorder (BD), both during and between mood episodes. We hypothesize that helping people with BD learn skills to create balance in their affective experiences by engaging in strategies that increase low activation positive emotion (LAP; e.g., relaxation) could help to improve well-being during periods of symptom remission. We discuss the development and preliminary outcomes of a positive emotion regulation (PER) group treatment for people with BD, designed as a supplement to pharmacological treatment.
Method:
The Learning Affective Understanding for a Rich Emotional Life (LAUREL) intervention is a group-based intervention covering 10 empirically supported skills designed to increase LAP. Sixteen people with BD enrolled in the LAUREL intervention and twelve completed baseline and post-intervention assessments.
Results:
Participants who completed the study (n = 12) attended the majority of groups (87.96%) and reported practicing skills, on average, 16 times a week. We were unable to detect significant differences in mania symptoms following engagement in this PER intervention. Finally, participants reported increases in several areas associated with well-being post-intervention, including mindfulness, reappraisal, and self-compassion.
Conclusion:
This study provides a theoretical framework and preliminary support for a PER intervention for BD.
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