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Protein-Protein Interactions in Candida albicans

Floris Schoeters^1,2, Patrick Van Dijck^1,2

¹VIB-KU Leuven Center for Microbiology, Leuven, Belgium.

Frontiers in Microbiology

|August 24, 2019

Summary

This study compiles known protein-protein interactions (PPIs) for Candida albicans, a key fungal pathogen. The findings aim to expand available data, crucial for understanding fungal biology and developing new antifungal drugs.

Area of Science:

Mycology
Molecular Biology
Bioinformatics

Background:

Candida albicans is a significant human fungal pathogen.
Existing protein-protein interaction (PPI) data for C. albicans is sparse in public databases.
Challenges exist in studying C. albicans PPIs due to non-canonical codon usage.

Purpose of the Study:

To compile an extensive and accessible list of known protein-protein interactions (PPIs) for Candida albicans.
To aid in the creation of comprehensive PPI networks for C. albicans.
To provide updated information for databases like BioGRID.

Main Methods:

Exhaustive literature search for C. albicans protein-protein interactions.
Data compilation and organization into an accessible format.

Main Results:

A more extensive list of known PPIs for Candida albicans was generated.
The compiled data aims to supplement existing, limited database entries.

Conclusions:

Enhanced PPI data is essential for understanding C. albicans biology, pathways, and potential drug targets.
This work facilitates further research into C. albicans pathogenesis and therapeutic strategies.

Keywords:

BioGRID Candida albicans Candida two-hybrid system S. cerevisiae protein-protein interactions yeast two-hybrid system

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