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[Role of the system of orexin/receptors in neurological diseases]

Jing Cui1, Wei-Yan Zhao2, Fei Cao1

  • 1College of Basic Medicine, Jining Medical University, Jining 272067, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|August 24, 2019
PubMed

Insights

The orexin system, including orexin and its receptors (OX1R, OX2R), regulates feeding behavior, sleep-wake cycles, and memory. This review explores its role in neurological diseases for future treatment guidance.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Pharmacology

Background:

  • The neuropeptide orexin is widely distributed throughout the nervous system.
  • Orexin signaling, via OX1R and OX2R, modulates feeding behavior and other physiological functions.
  • Emerging evidence links the orexin system to neurological diseases.

Purpose of the Study:

  • To review the current research on the orexin and its receptor system.
  • To elucidate the orexin system's function in physiological and pathological processes.
  • To highlight the correlation between orexin and nervous system disorders.

Main Methods:

  • Literature review of studies on orexin and its receptors.
  • Analysis of research on orexin's role in physiological processes.
  • Investigation of orexin system involvement in neurological diseases.

Main Results:

  • Orexin and its receptors are crucial for feeding behavior regulation.
  • The orexin system significantly impacts sleep-wake cycles, learning, and memory.
  • Dysregulation of the orexin system is implicated in various neurological conditions.

Conclusions:

  • The orexin system plays a multifaceted role in normal brain function.
  • Understanding the orexin system's involvement in disease offers therapeutic potential.
  • This review provides a foundation for future diagnostic and therapeutic strategies targeting orexin in neurological diseases.

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