Related Experiment Video
Updated: Jan 20, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
A physical activity intervention to prevent cognitive decline after stroke: Secondary results from the Life After
Hege Ihle-Hansen1, Birgitta Langhammer, Stian Lydersen
1Department of Geriatric, Oslo University Hospital, 0424 Oslo, Norway. hmihle@ous-hf.no.
Objective:
To examine the effects of individualized regular coaching and exercise on post-stroke cognitive and emotional function.
Methods:
The Life After STroke (LAST) study investigated the differences between intervention and care-as-usual between 3 and 21 months post-stroke. Outcome measures were the Trail Making Test (TMT) A and B, Mini Mental State Examination (MMSE), Hospital Anxiety and Depression Scale (HADS), and adherence to the intervention.
Results:
Of the 362 patients included in the study, 177 were assigned to the intervention. The mean age was 71.7 (SD 11.3) years and 39.5% were female. The adjusted mean difference between groups for TMT A was 8.54 (CI 0.7 to 16.3), p = 0.032, for TMT B 8.6 (CI -16.5 to 33.6), p = 0.50, for MMSE -0.1 (CI -0.8 to 0. 6), p = 0.77, for HADS A -0.2 (CI -0.9 to 0.5), p = 0.56 and for HADS D -0.1 (CI -0.7 to 0.5), p = 0.76). A higher level of adherence to the intervention was significantly associated with increased MMSE (B = 0.030 (CI 0.005-0.055), p = 0.020) Conclusion: No clinically relevant effects on cognitive or emotional function were found of individualized regular coaching for physical activity and exercise. However, increased adherence to the intervention was associated with improved cognitive function.
More Related Videos
Related Concept Videos
Secondary Active Transport
Secondary Active Transport
Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Cardiac Output and Stroke Volume
In an average resting adult male, the typical cardiac...
Half-life of a Reaction
Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...

