Related Experiment Video For Contrast-enhanced ultrasound
Updated: Jan 20, 2026

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
Published on: August 14, 2012
[Modern sonographic imaging of abdominal neuroendocrine tumors]
V Schwarze1, C Marschner2, S Grosu2
1Klinik und Poliklinik für Radiologie, Interdisziplinäres Ultraschallzentrum, Klinikum der Ludwig-Maximilians-Universität München, Campus Grosshadern, Marchioninistraße 15, 81377, München, Deutschland. vincent.schwarze@med.uni-muenchen.de.
Background:
Radiological and nuclear medical diagnostics play an important role in the work-up of patients with gastroenteropancreatic neuroendocrine tumors (GEP-NET). The sonographic examination, including contrast-enhanced examination, depicts an initial imaging modality to screen for NET. This report describes the sonomorphological behavior of ileal and pancreatic NET as well as hepatic metastases from NET.
Clinical/Methodical Issue:
Sonographic evaluation of NET of the small intestine, pancreas and neuroendocrine hepatic metastases.
Standard Radiological Methods:
Contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI), unenhanced ultrasonography.
Methodical Innovations:
Contrast-enhanced ultrasound (CEUS).
Performance:
CEUS supports unenhanced ultrasound in the detection of NET and the differential diagnosis of unclear lesions, and is more sensitive for liver metastases (sensitivity according to the literature, 99% vs. 68%) PRACTICAL RECOMMENDATIONS: CEUS allows initial evaluation of NET and differentiation of benign vs. malignant lesions. Nevertheless, CEUS cannot replace more elaborate imaging modalities like CT or MRI for thorough staging examinations.
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