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Updated: Jan 20, 2026
Mouse Pneumonectomy Model of Compensatory Lung Growth
Published on: December 17, 2014
Factors associated with compensatory lung growth after pulmonary lobectomy for lung malignancy: an analysis of lung
Ikuma Wakamatsu1, Haruhisa Matsuguma2, Rie Nakahara2
1Division of Thoracic Surgery, Tochigi Cancer Center, 4-9-13 Yohnan, Utsunomiya, 320-0834, Tochigi, Japan. ikumwaka@tochigi-cc.jp.
Purpose:
To establish the factors associated with compensatory lung growth (CLG) in human adults.
Methods:
The subjects of this study were 216 patients who underwent pulmonary lobectomy between January 2008 and March 2015 and had computed tomography (CT) scans done before and 2 years after surgery with no signs of recurrence. The predicted postoperative values of lung volume and lung weight, based on the preoperative CT data, were compared with those 2 years after surgery.
Results:
When the predicted postoperative values were considered to be 100%, the mean lung volume and lung weight 2 years after surgery were 116 ± 16% and 115 ± 19%, respectively. CLG was defined as both lung volume ≥ 110% and lung weight ≥ 106% (CLG group; n = 108). Both univariate and multivariate analyses showed that younger age (≤ 60 years), a larger number of resected subsegments (≥ 10), and a light- (< 20 pack-years) or non-smoking history were significantly associated with CLG.
Conclusions:
This study identified younger age, a light- or non-smoking history, and a large resection volume as the predictors of CLG in patients who underwent pulmonary lobectomy for lung malignancy. All of these three factors may be reasonably connected to CLG.
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