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Genotyping Approach for Potential Common Source of Enterocytozoon bieneusi Infection in Hematology Unit

Guillaume Desoubeaux, Céline Nourrisson, Maxime Moniot

    Emerging Infectious Diseases
    |August 24, 2019
    PubMed

    Insights

    Three patients with hematologic malignancies were diagnosed with Enterocytozoon bieneusi microsporidiosis. Genetic analysis confirmed an epidemiologic link and a common source of infection for these cases.

    Area of Science:

    • Medical Mycology
    • Infectious Diseases
    • Genetics

    Background:

    • Microsporidiosis, a fungal infection, commonly causes gastrointestinal issues, particularly in immunocompromised individuals.
    • Hematologic malignancy patients are susceptible to opportunistic infections like microsporidiosis.

    Purpose of the Study:

    • To investigate an unusual cluster of three Enterocytozoon bieneusi microsporidiosis cases in a French hospital's hematology unit.
    • To determine the genetic relationship and potential common source of infection among the diagnosed patients.

    Main Methods:

    • Sequence analysis of the internal transcribed spacer rDNA locus.
    • Multilocus genotyping using microsatellite and minisatellite markers.
    • Comparative genetic analysis of patient isolates against existing strain databases.

    Main Results:

    • All three patient isolates exhibited significant sequence similarities, indicating a shared origin.
    • The isolates represented a novel genotype, closely related to known genotype C.
    • Multilocus genotyping revealed substantial genetic divergence from unrelated strains, confirming the distinctness of the new genotype.

    Conclusions:

    • The genetic data strongly support an epidemiologic link among the three patients.
    • A common source of Enterocytozoon bieneusi infection was identified as the likely cause of the cluster.
    Keywords:
    Enterocytozoon bieneusiFranceITS rDNAclusterepidemiologyfungigenotypingmicrosporidiamicrosporidiosisoutbreaksatellites

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