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Updated: Jan 20, 2026

Orthotopic Mouse Model of Colorectal Cancer
Published on: December 4, 2007
Hsp70 inhibitors: Implications for the treatment of colorectal cancer
Reyhaneh Moradi-Marjaneh1, Maryam Paseban2, Mahdi Moradi Marjaneh3
1Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Abstract:
Colorectal cancer (CRC) is one of the most common malignancies in the world. Despite intensive advances in diagnosis and treatment of CRC, it is yet one of the leading cause of cancer related morbidity and mortality. Therefore, there is an urgent medical need for alternative therapeutic approaches to treat CRC. The 70 kDa heat shock proteins (Hsp70s) are a family of evolutionary conserved heat shock proteins, which play an important role in cell homeostasis and survival. They overexpress in various types of malignancy including CRC and are typically accompanied with poor prognosis. Hence, inhibition of Hsp70 may be considered as a striking chemotherapeutic avenue. This review summarizes the current knowledge on the progress made so far to discover compounds, which target the Hsp70 family, with particular emphasis on their efficacy in treatment of CRC. We also briefly explain the induction of Hsp70 as a strategy to prevent CRC.
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