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Vaccine Effectiveness against DS-1-Like Rotavirus Strains in Infants with Acute Gastroenteritis, Malawi, 2013-2015

Khuzwayo C Jere, Naor Bar-Zeev, Adams Chande

    Emerging Infectious Diseases
    |August 24, 2019
    PubMed

    Insights

    Rotavirus vaccine protected infants against new G1P[8] strains that emerged in Malawi. Despite the strains appearing after vaccine introduction, effectiveness was high at 85.6%.

    Area of Science:

    • Virology
    • Vaccinology
    • Pediatric Gastroenterology

    Background:

    • Atypical DS-1-like G1P[8] rotaviruses emerged in Malawi in 2013.
    • This emergence coincided with the introduction of rotavirus vaccination programs.

    Purpose of the Study:

    • To evaluate the effectiveness of the rotavirus vaccine against the newly emerged DS-1-like G1P[8] strains.

    Main Methods:

    • Case-control study design.
    • Analysis of infants hospitalized with acute gastroenteritis.
    • Genotyping of rotavirus strains.

    Main Results:

    • Vaccine effectiveness against DS-1-like G1P[8] rotavirus gastroenteritis was 85.6% (95% CI 34.4%-96.8%).
    • The vaccine demonstrated significant protection despite the emergence of these strains post-introduction.

    Conclusions:

    • The rotavirus vaccine provides robust protection against emerging DS-1-like G1P[8] strains.
    • Vaccination remains a critical tool for preventing severe rotavirus disease, even with evolving viral strains.
    Keywords:
    Malawigenome constellationgenotypinginfantsrotavirusvaccine effectivenessvaccinesviruseswhole-genome sequencing

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