Related Experiment Video

Updated: Jan 20, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.6K

Expanded Series and Personalized Patch Tests for Children: A Retrospective Cohort Study

Reid W Collis1, Gabriela M Morris2, David M Sheinbein3

  • 1From the Washington University in St Louis School of Medicine.

Dermatitis : Contact, Atopic, Occupational, Drug
|August 24, 2019
PubMed

Insights

Expanded patch testing in children reveals common reactions to allergens not found in the T.R.U.E. Test, highlighting the need for broader diagnostic approaches for allergic contact dermatitis (ACD). Cocamidopropyl betaine was a frequent culprit.

Area of Science:

  • Dermatology
  • Pediatric Allergy
  • Contact Dermatitis Research

Background:

  • Epicutaneous patch testing is crucial for diagnosing allergic contact dermatitis (ACD).
  • A standardized approach to patch testing in pediatric populations is currently lacking.
  • Existing diagnostic tools may not capture all relevant allergens in children.

Purpose of the Study:

  • To evaluate patch test positivity in pediatric patients with suspected ACD, differentiating between those with and without atopic dermatitis history.
  • To compare the diagnostic yield of the North American 80 Comprehensive Series and personalized patch tests against the Thin-Layer Rapid Use Epicutaneous (T.R.U.E.) Test.
  • To identify common allergen exposures in pediatric ACD cases.

Main Methods:

  • Analysis of pediatric patients undergoing North American 80 Comprehensive Series or personalized patch testing.
  • Assessment of allergen sensitization 48–72 hours post-patch removal.
  • Comparison of results between comprehensive/personalized tests and the T.R.U.E. Test, stratified by atopic dermatitis history.

Main Results:

  • Out of 29 pediatric patients, 25 showed at least one positive reaction (81 total reactions).
  • Nearly half (49.4%) of reactions were from allergens not included in the T.R.U.E. Test.
  • Cocamidopropyl betaine was a significant allergen, particularly in patients with atopic dermatitis.

Conclusions:

  • Expanded and personalized patch testing offer a more thorough allergen inventory than the T.R.U.E. Test for pediatric ACD.
  • Pediatric patients frequently react to allergens found in household products but absent from standard T.R.U.E. Test panels.
  • Enhanced patch testing and patient counseling are recommended for managing pediatric ACD.
Abstract

More Related Videos

Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education09:00

Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education

Published on: August 16, 2024

1.2K
Studying Brain Function in Children Using Magnetoencephalography08:00

Studying Brain Function in Children Using Magnetoencephalography

Published on: April 8, 2019

9.6K

Related Concept Videos

Self-Report Tests of Personality01:22

Self-Report Tests of Personality

Self-report inventories are objective personality assessments that use multiple-choice items or numbered scales, typically ranging from 1 (strongly disagree) to 5 (strongly agree). They are often called Likert scales after Rensis Likert. These inventories are widely used due to their ease of administration and cost-effectiveness. One of the most prominent examples is the Minnesota Multiphasic Personality Inventory (MMPI), initially developed in the 1940s to assess abnormal personality traits.
782
Resistors In Series01:10

Resistors In Series

A resistor is an ohmic device that limits the flow of charge in a circuit. Most circuits have more than one resistor. If several resistors are connected together and connected to a battery, the current supplied by the battery depends on the equivalent resistance of the circuit. The equivalent resistance of a combination of resistors depends on both their individual values and how they are connected. The simplest combination of resistors is the series combination. 
In a series circuit, the...
6.1K
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
7.9K
Series Resonance01:17

Series Resonance

The RLC circuit impedance is defined as the ratio of the supply voltage to the circuit current. Resonance in such a circuit occurs when the imaginary part of this impedance equals zero. This specific condition means that the inductive reactance is exactly equal to the capacitive reactance. The frequency at which this happens is known as the resonant frequency. Mathematically, the resonant frequency is inversely proportional to the square root of the product of the inductance (L) and capacitance...
763
Trigonometric Fourier series01:17

Trigonometric Fourier series

Fourier series is a foundational mathematical technique that decomposes periodic functions into an infinite series of sinusoidal harmonics. This method enables the representation of complex periodic signals as sums of simple sine and cosine functions, facilitating their analysis and interpretation in various fields, including signal processing, acoustics, and electrical engineering.
The trigonometric Fourier series specifically expresses a periodic function with a defined period T using sine...
755
Convergence of Fourier Series01:21

Convergence of Fourier Series

The Fourier series is a powerful mathematical tool for representing periodic signals as an infinite sum of complex exponentials. In practice, this infinite series is truncated to a finite number of terms, yielding a partial sum. This truncation makes the approximation of the signal feasible but introduces certain challenges, particularly near discontinuities, known as the Gibbs phenomenon.
The Gibbs phenomenon refers to the persistent oscillations and overshoots that occur near discontinuities...
383