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Ozone and pulsed electro-magnetic field therapies improve endometrial lining thickness in frozen embryo transfer
Zaher Merhi1,2, Rajean Moseley-LaRue3, Amber Ray Moseley3
1Department of Biochemistry, Albert Einstein College of Medicine Bronx.
Rationale:
In assisted reproductive technology, a persistently thin endometrial lining represents a huge challenge during frozen embryo transfer (FET) cycles.
Patient Concerns:
Three patients who had a persistently thin endometrial lining despite the use of several medical agents known to improve endometrial lining thickness.
Diagnoses:
Infertility undergoing FET cycles.
Interventions:
A combination of transdermal and intravaginal ozone therapy along with Pulsed Electro-Magnetic Field (PEMF) therapy.
Outcomes:
Ozone with PEMF, both of which are known to have vasodilatatory, anti-inflammatory, and anti-oxidant actions, were successful in improving the thickness of the endometrial lining in all 3 patients. Two out of 3 patients became pregnant following single embryo transfer.
Lessons:
Ozone with PEMF constitute a novel experimental approach for women with persistently thin endometrial lining undergoing FET. This novel approach needs validation by large well-designed studies.
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