Related Experiment Video
Updated: Aug 12, 2026

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
Published on: April 26, 2015
Abstract:
A standard experimental shock model was used to investigate the nature and treatment of refractory shock. Peripheral vasodilatation secondary to hypoxia appeared to be the primary problem in pathogenesis, such factors as myocardial or reticuloendothelial depression being of a secondary nature. Protease inhibition using aprotinin (Trasylol) was ineffective in therapy, but glucocorticoids in pharmacological dosage produced a significant improvement in cardiodynamic and oxygen metabolic factors, provided that the agent was administered early.
Related Concept Videos
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Blood Pressure Imbalances and Circulatory Shock
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Cardiopulmonary Resuscitation IV: Pharmacological Management
Heart Failure V: Medical Management
Heart Failure VI: Adjunct Therapies

