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Target highlights in CASP13: Experimental target structures through the eyes of their authors

Rosalba Lepore1, Andriy Kryshtafovych2, Markus Alahuhta3

  • 1BSC-CNS Barcelona Supercomputing Center, Barcelona, Spain.

Proteins
|August 24, 2019
PubMed

Insights

Structural biologists evaluated the functional significance of CASP13 targets, assessing how well their predicted structures matched the actual protein features. This analysis aids in understanding protein structure prediction accuracy.

Area of Science:

  • Structural biology
  • Computational biology
  • Biochemistry

Background:

  • The Critical Assessment of protein Structure Prediction (CASP) experiment benchmarks protein structure prediction methods.
  • Understanding the functional and biological significance of protein targets is crucial for biological research.

Purpose of the Study:

  • To describe the functional and biological significance of selected CASP13 targets.
  • To assess the accuracy of protein structure predictions submitted to CASP13 by analyzing key structural features.

Main Methods:

  • Authors of protein structures for CASP13 targets provide descriptions.
  • Structural biologists analyze and compare predicted structures against experimentally determined ones.
  • Evaluation of specific, interesting structural features in target proteins.

Main Results:

  • Descriptions of the functional and biological roles of selected CASP13 targets are provided.
  • Key structural features of target proteins are identified and discussed.
  • An assessment of the accuracy of reproduced structural features in CASP13 predictions is presented.

Conclusions:

  • The study highlights the importance of accurately predicting protein structures for understanding biological function.
  • Assessing structural features aids in validating computational prediction models.
  • Findings contribute to the ongoing improvement of protein structure prediction methodologies.
Keywords:
CASP, protein structure predictionX-ray crystallographycryo-EM

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