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Novel therapeutic interventions in cancer treatment using protein and peptide-based targeted smart systems

Sobiya Zafar1, Sarwar Beg1, Sunil K Panda2

  • 1Nanomedicine Research Lab, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, India.

Seminars in Cancer Biology
|August 24, 2019
PubMed

Insights

Peptides show promise for targeted cancer therapy and diagnosis by utilizing patient-specific markers. Peptide-modified nanomedicines offer potential for enhanced delivery of anticancer agents.

Area of Science:

  • Oncology
  • Nanomedicine
  • Biotechnology

Background:

  • Cancer remains a significant global health challenge, necessitating innovative treatment strategies.
  • Personalized/precision medicine is revolutionizing cancer care by leveraging patient- and tumor-specific markers.
  • Peptides offer a promising avenue for developing targeted cancer therapies and diagnostic tools.

Purpose of the Study:

  • To review the benefits and drawbacks of peptides in cancer therapeutics.
  • To explore the potential of peptide-modified nanomedicines for targeted anticancer drug delivery.

Main Methods:

  • Review of current literature on peptide-based cancer therapies.
  • Analysis of advancements in combinatorial peptide libraries.
  • Evaluation of peptide-modified nanomedicine strategies for targeted delivery.

Main Results:

  • Peptides can be designed to target cancer-specific signatures, enabling precise therapeutic interventions.
  • Combinatorial peptide libraries facilitate the development of multifunctional peptide-based materials.
  • Peptide-modified nanomedicines show potential for improving the efficacy and reducing the side effects of anticancer agents.

Conclusions:

  • Peptides represent a valuable class of molecules for advancing targeted cancer therapy and diagnosis.
  • Further research into peptide-based nanomedicines is warranted to optimize their clinical application.
  • Personalized medicine approaches integrating peptide therapeutics hold significant promise for future cancer management.
Keywords:
CancerCellular immunologyNanomedicinesPeptidesProtein

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