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Compression stockings to prevent post-thrombotic syndrome in adults, a Bayesian meta-analysis
M L Avila1, M Montoya1, C Lumia1
1Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Thrombosis Research
|August 24, 2019
Summary
Compression stockings may offer some benefit in preventing post-thrombotic syndrome (PTS) after deep vein thrombosis. Probabilities suggest a potential treatment benefit, even with study variations.
Area of Science:
- Vascular Medicine
- Clinical Epidemiology
Background:
- The effectiveness of compression stockings for preventing post-thrombotic syndrome (PTS) after deep vein thrombosis (DVT) remains debated.
- This study aims to quantify the efficacy of compression stockings compared to no intervention in preventing PTS.
Purpose of the Study:
- To estimate the efficacy of compression stockings in preventing PTS.
- To determine the probability of observing treatment benefits with compression stockings.
Main Methods:
- Systematic review of randomized controlled trials (RCTs) from major databases (MEDLINE, EMBASE, Cochrane).
- Inclusion of studies comparing compression stockings in the acute DVT setting versus control.
- Bayesian statistical approach for data analysis.
Main Results:
- Analysis of four RCTs revealed an odds ratio (OR) of 0.57 for any PTS and 0.79 for severe PTS.
- Probabilities of observing treatment benefit ranged from 47%-95% for any PTS and 16%-82% for severe PTS.
- Future study benefits were estimated between 44%-76% for any PTS and 25%-72% for severe PTS.
Conclusions:
- Despite study heterogeneity, evidence suggests a probable treatment benefit from compression stockings for PTS prevention.
- There is a likelihood of observing benefits in both the current patient population and future research.
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