Recent progress in biomedical applications of chitosan and its nanocomposites in aquaculture: A review

Chitosan nanoparticles (CSNPs) are the nanostructures of chitosan biopolymer which is derived from chitin polysaccharide, the main component of crustacean shells. Chitosan is a biocompatible, nontoxic and biodegradable polymer soluble in acidic solutions and easily excreted from kidneys. It is widely used in medical and pharmaceutical applications including artificial matrices for tissue engineering, drug transport, targeted drug delivery and protein or gene delivery. The antimicrobial activities of chitosan and CSNPS against different bacterial, fungal and viral pathogens made them valuable for several biological applications including food preservation purposes. In addition, they have immunomodulatory effects on fish and crustaceans providing direct positive impact on aquaculture and fish farming industry. Sustained release of some bioactive ingredients such as hormones, vitamins, nutrients and antioxidants has improved the biological activities of fish. Furthermore, CSNPs have recently been employed to diagnose fish diseases. In this review, we present the medical and biological applications of chitosan and CSNPs on aquatics to provide an update on recent advances and the potential for further advanced applications for aquaculture in the future.