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Updated: Jan 20, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
Development and evaluation of a 99mTc(V)-nitrido complex derived from estradiol for breast cancer imaging
Emilia Tejería1, Javier Giglio1, Leticia Fernández1
1Área de Radioquímica, Facultad de Química, General Flores 2124, Universidad de La República, 11800, Montevideo, Uruguay.
Abstract:
Estrogen receptors are overexpressed in 70% of breast cancer and identification of their presence is important to select the appropriate treatment. This work proposes the preparation and evaluation of an estradiol derived as potential ER imaging agent. Ethinylestradiol was derivatized to introduce a dithiocarbamate function for Tc coordination. Labeling was achieved through the formation of a symmetric Tc(V)-nitrido complex with a radiochemical purity (RCP) > 95%. Physicochemical evaluation, cell uptake, biodistribution in normal animals and in nude mice bearing induced ER + breast tumors showed promising results.
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