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Using a Revised Protein-Sparing Modified Fast (rPSMF) for Children and Adolescents with Severe Obesity: A Pilot Study
Ihuoma Eneli1,2, Jinyu Xu3, Alexis Tindall3
1Center for Healthy Weight and Nutrition, Nationwide Children's Hospital, Columbus, OH 43205, USA. Ihuoma.eneli@nationwidechildrens.org.
Summary
A revised protein-sparing modified fast (PSMF) diet showed significant weight loss and improved quality of life in adolescents with severe obesity, despite adherence challenges.
Area of Science:
- Pediatric Endocrinology
- Bariatric Medicine
- Nutritional Science
Background:
- Severe obesity in children and adolescents has limited treatment options.
- The protein-sparing modified fast (PSMF) is a potential intervention for substantial weight loss.
Purpose of the Study:
- To assess the adherence and effectiveness of a revised PSMF (rPSMF) in a pediatric weight-management program.
- To evaluate the impact of rPSMF on weight and quality of life in severely obese youth.
Main Methods:
- A 12-month rPSMF intervention was implemented with 1200-1800 calories, 40-60g carbohydrates/day, and 1.2-1.5g protein/kg ideal body weight.
- Twenty-one participants (mean age 16.2 years, 76.2% female) with severe obesity were enrolled.
Main Results:
- Mean weight changes at 1, 3, and 6 months were -3.7kg, -5.5kg, and -4.7kg respectively.
- At 12 months, mean weight change was -1.3kg, with significant individual variability.
- Physical and psychosocial quality of life (HRQOL) improved for both parents and children.
Conclusions:
- Despite challenges with adherence, the rPSMF diet achieved clinically significant weight loss in severely obese children and adolescents.
- The rPSMF intervention positively impacted the health-related quality of life in this pediatric population.
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