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An Effective Mouse Model of Unilateral Renal Ischemia-Reperfusion Injury
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Opioids Preconditioning Upon Renal Function and Ischemia-Reperfusion Injury: A Narrative Review

Julio Palomino1, Raquel Echavarria2, Adriana Franco-Acevedo3

  • 1School of Medicine, Universidad Durango-Santander, Hermosillo 83165, Mexico.

Medicina (Kaunas, Lithuania)
|August 25, 2019
PubMed

Insights

Opioid preconditioning may protect kidneys from damage after injury or transplantation by reducing inflammation and oxidative stress. This strategy shows promise for improving outcomes in acute renal injury and kidney transplant patients.

Area of Science:

  • Nephrology
  • Anesthesiology
  • Immunology

Background:

  • Kidneys are vital for homeostasis, regulating fluid balance, blood pressure, and electrolytes.
  • Kidney injury can lead to chronic kidney disease, with limited treatment options in late stages.
  • Kidney transplantation is challenged by immune activation and oxidative stress in grafts.

Purpose of the Study:

  • To review renal physiology and the impact of anesthetic preconditioning on kidney function.
  • To focus on the renoprotective properties of opioids in mitigating ischemia reperfusion injury.
  • To evaluate the potential clinical application of opioid preconditioning in renal care.

Main Methods:

  • Literature review of renal physiology.
  • Analysis of studies on anesthetic preconditioning effects on renal function.
  • Focus on evidence regarding opioid preconditioning and ischemia reperfusion injury.

Main Results:

  • Anesthetic preconditioning is a potential strategy to reduce ischemia reperfusion injury.
  • Opioid preconditioning demonstrated a reduction in inflammation and reactive oxygen species post-ischemia reperfusion.
  • Evidence suggests opioids possess properties that ameliorate renal injury.

Conclusions:

  • Opioid preconditioning is a promising approach to minimize renal ischemia reperfusion injury.
  • Clinical application of opioid preconditioning could benefit patients with acute renal injury and kidney transplants.
  • Further research into opioid preconditioning may enhance graft survival and renal function post-transplant.
Keywords:
fentanylischemia-reperfusion injurykidneymorphineopioid preconditioning

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