The REVAMP study: research exploring various aspects and mechanisms in preeclampsia: study protocol

Area of Science:

• Obstetrics and Gynecology
• Nutritional Science
• Developmental Biology

Background:

• Preeclampsia poses significant risks to maternal and infant health globally.
• Understanding preeclampsia etiology is crucial for effective prevention and treatment.
• Dietary long-chain polyunsaturated fatty acids (LCPUFA) are implicated in pathways relevant to preeclampsia.

Purpose of the Study:

• To longitudinally examine the association between maternal LCPUFA levels and preeclampsia outcomes.
• To investigate the role of LCPUFA in the biochemical and molecular mechanisms of preeclampsia.
• To explore the relationship between LCPUFA, preeclampsia, and developmental programming in children.

Main Methods:

• The REVAMP study prospectively follows a cohort of pregnant women from early gestation to delivery.
• Data collection includes personal, obstetric, clinical history, anthropometry, FFQ, physical activity, and socioeconomic status.
• Biological samples (maternal blood, cord blood, placenta) are collected and stored for analysis. Fetal and infant assessments are conducted up to age 2.

Main Results:

• Data collection and sample acquisition are ongoing.
• Analysis will focus on associations between LCPUFA and preeclampsia development and severity.
• Further analysis will explore LCPUFA's role in fetal development and long-term child outcomes.

Conclusions:

• This research aims to facilitate early identification of women at risk for preeclampsia.
• The study will elucidate the role of LCPUFA in preeclampsia pathogenesis and its impact on child development.
• Findings are expected to inform potential dietary interventions for preeclampsia prevention.