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Updated: Jan 20, 2026
09:40
Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
Published on: November 28, 2018
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Prognostic value of long non-coding RNA 01296 expression in human solid malignant tumours: a meta-analysis
Chen Dai1, Chenguang Dai2, Hao Ni3
1General Surgery, First Affiliated Hospital of Soochow University, Suzhou, China.
Postgraduate Medical Journal
|August 25, 2019
Summary
High expression of long intergenic non-coding RNA 01296 (LINC01296) is linked to aggressive features in solid tumors. This finding suggests LINC01296 may serve as a valuable prognostic biomarker for cancer patients.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long intergenic non-coding RNA 01296 (LINC01296) has a known role in human malignancies, but its prognostic significance requires further clarification.
- Existing research presents a fragmented view on the role of LINC01296 in various cancers.
Purpose of the Study:
- To conduct a meta-analysis to determine the prognostic value of LINC01296 in human solid malignant tumors.
- To consolidate evidence regarding the association between LINC01296 expression and clinical outcomes in cancer patients.
Main Methods:
- A comprehensive electronic literature search was performed across multiple databases (PubMed, EMBASE, Web of Science, CNKI, Cochrane Library, CBML, WanFang).
- Eligible studies were selected, and pooled odds ratios (ORs) or hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated.
- Data from nine studies involving 559 patients were analyzed.
Main Results:
- High LINC01296 expression correlated significantly with larger tumor size (OR 3.42), lymph node metastasis (OR 3.03), and advanced TNM stage (OR 4.41).
- Elevated LINC01296 expression was a predictor of poor overall survival (HR 1.78) and recurrence-free survival (HR 4.00).
Conclusions:
- High LINC01296 expression is associated with unfavorable clinical outcomes in cancer patients.
- LINC01296 demonstrates potential as a prognostic biomarker for human solid malignant tumors.
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