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Published on: January 22, 2016
A complicated case of bowel obstruction with sepsis and methamphetamine toxicity in a child with pica
Christine Stevens1, Erinn Ton2, Prentiss Jones2
1Western Michigan University Homer Stryker M.D. School of Medicine, 276 Portage Street #200, Kalamazoo, MI, 49007, USA. christine.stevens@med.wmich.edu.
Insights
A pediatric case highlights that children with pica may ingest foreign objects and drugs, leading to bowel obstruction and sepsis. Methamphetamine toxicity can mimic these symptoms, necessitating broader diagnostic considerations in affected children.
Area of Science:
- Pediatric Toxicology
- Gastrointestinal Pathology
- Forensic Medicine
Background:
- Pica, the persistent eating of non-nutritive, non-food substances, is a recognized condition in children.
- Accidental drug ingestion is typically considered less common in children over five years old.
- Bowel obstruction and sepsis are serious conditions in pediatric patients.
Observation:
- An eleven-year-old female with a history of pica presented with unresponsiveness and was pronounced deceased.
- Radiologic imaging revealed multiple radio-opaque foreign objects in the gastrointestinal tract.
- Autopsy confirmed foreign material ingestion and postmortem toxicology identified amphetamine and methamphetamine.
Findings:
- The autopsy findings were consistent with bowel obstruction and sepsis secondary to foreign material ingestion.
- High methamphetamine concentrations suggested concurrent methamphetamine toxicity.
- Methamphetamine toxicity and bowel obstruction can present with similar clinical signs in children.
Implications:
- The age range for suspecting accidental drug ingestion should be expanded for children with pica.
- Pediatric patients with pica presenting with bowel obstruction symptoms warrant consideration for unintentional drug ingestion.
- Awareness of potential co-occurrence of pica-related foreign body ingestion and drug toxicity is crucial, especially in environments with substance abuse.
Abstract:
In this report, a pediatric case of bowel obstruction with sepsis complicated by methamphetamine toxicity is described. The decedent, an eleven-year-old female with a clinical history of pica, was found unresponsive in her home and pronounced dead following unsuccessful resuscitative efforts. Radiologic imaging showed multiple radio-opaque foreign objects in the stomach and bowel. Autopsy revealed a green leafy substance, coins and other metallic items, folded paper, and plastic in her stomach and bowels. Postmortem iliac blood and urine tested positive for amphetamine and methamphetamine. While the decedent's medical history and autopsy findings provided evidence consistent with bowel obstruction with sepsis due to the ingestion of foreign materials, the high methamphetamine concentration was suggestive of concurrent methamphetamine toxicity. Unique complications associated with this case include the phenomenon that methamphetamine toxicity and bowel obstruction can present similarly in children and the reported opinion that accidental drug ingestion is uncommon in children over the age of five. This case emphasizes that the age range for suspected accidental drug ingestion should be expanded for those with pica, as these patients, despite being older, may not be able to differentiate between what they should and should not ingest. Furthermore, when treating a pediatric patient with pica that appears to present with bowel obstruction, unintentional drug ingestion should also be considered, particularly if there is a suspicion that the child lives in a household where drugs are abused, given the prospect that drug toxicity can present similarly.
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