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Updated: Jan 20, 2026

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
Published on: February 20, 2020
Leishmania amazonensis inorganic phosphate transporter system is increased in the proliferative forms
Luiz Fernando Carvalho-Kelly1, André Luiz Gomes-Vieira2, Lisvane Paes-Vieira1
1Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Abstract:
Here we characterize a high-affinity Pi transport system energized by a H+ gradient in Leishmania amazonensis. Pi uptake and transcription of LamPho84 gene are differentially regulated during parasite life cycle. Our data suggest that Pi acquisition could be a pivotal task for the success of the parasite throughout its life cycle.
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