Related Experiment Video
Updated: Jan 20, 2026

Quantifying the Antifungal Activity of Peptides Against Candida albicans
Published on: January 13, 2023
Antifungal activity and tautomeric cyclization equilibria of formylphenylboronic acids
Krzysztof M Borys1, Dorota Wieczorek2, Kamila Pecura1
1Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland.
Abstract:
2-Formylphenylboronic acid and four isomeric fluoro-2-formylphenylboronic acids have been found active against a series of fungal strains: Aspergillus, Fusarium, Penicillium and Candida. The level of antifungal activity was evaluated by agar diffusion tests as well as the determination of minimum inhibitory concentrations (MICs) by serial dilution method. Among the tested compounds, 4-fluoro-2-formylphenylboronic acid - an analogue of the known antifungal drug Tavaborole (AN2690) - proved to be the most potent antifungal agent. The tautomeric equilibrium leading to the formation of 3-hydroxybenzoxaboroles as well as the position of the fluorine substituent were revealed to play a crucial role in the observed activity.
Related Concept Videos
Acid–Base Equilibria: Activity-Based Definition of pH
In solutions of very low ionic strength—for example, pure water—the...
Ladder Diagrams: Acid–Base Equilibria
A ladder diagram for acid-base equilibria consists of a vertical axis that represents pH and horizontal bars (steps on the ladder) that help position all the pKa values in the system. At equilibrium, the pH value of the system corresponds to one of...
Keto–Enol Tautomerism: Mechanism
Solubility Equilibria
The...
Solubility Equilibria: Overview
Solubility is important in biological and environmental processes. A notable...
Complexation Equilibria: The Chelate Effect

