Intermediate-Term Outcomes of Slide Tracheoplasty in Pediatric Patients With Ring-Sling Complex

Hao Chen1, Guocheng Shi1, Limin Zhu1

  • 1Department of Cardiothoracic Surgery, Heart Center, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Insights

Slide tracheoplasty (STP) shows satisfactory intermediate outcomes for patients with ring-sling complex. Careful preoperative recognition and postoperative surveillance are crucial for Type 2B patients with complex tracheobronchial anomalies.

Area of Science:

  • Pediatric Surgery
  • Thoracic Surgery
  • Respiratory Medicine

Background:

  • Ring-sling complex is a rare congenital anomaly affecting the trachea and bronchi.
  • Slide tracheoplasty (STP) is a surgical technique used to treat complex airway stenoses.
  • Understanding intermediate-term outcomes of STP in this patient population is essential for clinical management.

Purpose of the Study:

  • To evaluate the intermediate-term outcomes of slide tracheoplasty (STP) in children with ring-sling complex.
  • To identify factors associated with adverse outcomes after STP.

Main Methods:

  • Retrospective review of all children undergoing STP between 2009 and 2018.
  • Analysis of baseline characteristics, perioperative management, and follow-up data.
  • Multivariate analysis to determine predictors of complications.

Main Results:

  • 7 in-hospital and 8 late deaths occurred; median follow-up was 2.1 years.
  • Type 2B patients (Wells' classification) showed higher rates of malacia and restenosis.
  • Associated cardiovascular anomalies, carinal stenosis, and bronchial stenosis were linked to increased tracheomalacia, restenosis, and mortality.

Conclusions:

  • Slide tracheoplasty demonstrates satisfactory intermediate-term outcomes in patients with ring-sling complex.
  • Type 2B patients represent a high-risk group requiring specialized preoperative and postoperative care.
  • Identifying and managing associated anomalies is critical for improving surgical results.
Abstract

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
214
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
261
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
196
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
250
Disassembly of Intermediate Filaments01:35

Disassembly of Intermediate Filaments

Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to regulate their disassembly. The IF concentration in the cytoplasm also regulates the disassembly. If the concentration crosses a threshold, it activates the protein kinases in the vicinity, allowing the phosphorylation of IFs.
Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...
2.6K
Types of Intermediate Filaments01:31

Types of Intermediate Filaments

The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...
4.8K