Interval and continuous exercise overcome memory deficits related to β-Amyloid accumulation through modulating
Baixia Li1, Fei Liang1, Xiaoyan Ding1
1Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai, China; School of Physical Education and Health, East China Normal University, Shanghai, China.
Behavioural Brain Research
|August 26, 2019
Summary
Both high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) improved cognitive function in mice with Alzheimer's disease. Exercise enhanced mitochondrial health and reduced amyloid-beta burden in the hippocampus.
Area of Science:
- Neuroscience
- Exercise Physiology
- Mitochondrial Biology
Background:
- Exercise is a non-pharmacological approach for cognitive health.
- Optimal exercise types for cognitive benefits remain unclear.
- Mitochondrial function is linked to both exercise capacity and cognitive function.
Purpose of the Study:
- To investigate the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on cognitive function.
- To examine the impact of HIIT and MICT on mitochondrial dynamics in Alzheimer's disease (AD) mouse models.
- To explore the relationship between exercise, amyloid-beta (Aβ) burden, and mitochondrial health in the hippocampus.
Main Methods:
- APP/PS1 transgenic mice were subjected to 12 weeks of either HIIT or MICT.
- Cognitive function was assessed through exploratory behavior, spatial learning, and memory tests.
- Hippocampal tissues were analyzed for Aβ levels, mitochondrial morphology, protein expression related to mitochondrial dynamics (DRP1, FIS1, MFN1, MFN2, OPA1), and oxidative stress markers (ROS, MDA, H2O2, SOD, CAT).
Main Results:
- Both HIIT and MICT significantly improved exploratory behavior, spatial learning, and memory in APP/PS1 mice.
- Exercise interventions reduced hippocampal Aβ burden and improved mitochondrial morphology, decreasing fragmentation.
- HIIT and MICT modulated the expression of key mitochondrial dynamics proteins and reduced oxidative stress markers while enhancing antioxidant enzyme activity.
Conclusions:
- Both HIIT and MICT are effective in alleviating cognitive decline in an AD mouse model.
- Exercise-induced cognitive benefits may be mediated by improvements in mitochondrial morphology and dynamics.
- Exercise interventions positively impact Aβ pathology and oxidative stress in the hippocampus.
Keywords:
Alzheimer’s diseaseExerciseHigh-intensity interval trainingMitochondrial fusion/fissionModerate-intensity continuous trainingMore Related Videos
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