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Updated: Jan 20, 2026

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
Published on: June 14, 2018
Development and validation of an LC-MS/MS method for the simultaneous determination of bedaquiline and rifabutin in
Wesley A Gray1, Byron Waldorf1, Manasa Geeta Rao1
1The University of Toledo, Department of Pediatrics, 3000 Arlington Ave., Toledo, OH 43614, USA.
Abstract:
This article describes the simultaneous determination of bedaquiline fumarate (TMC-207) and rifabutin in human plasma by stable isotope dilution tandem mass spectrometry. The methodology was developed for an investigation of potential drug-drug interactions of the two anti-tuberculosis drugs when given together to healthy human volunteers. Use of the two drugs in combination to treat disease caused by Mycobacterium tuberculosis is contemplated as the bacterium becomes resistant to many currently available drugs.
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