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Published on: May 27, 2015
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Bioactive glycosides from Salacia cochinchinensis
Hui-Mei You1, Jia-Wen Zhao1, Yu-Xing Jing1
1Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Chenggong New District, Kunming, Yunnan, 650500, China.
Carbohydrate Research
|August 26, 2019
Summary
Four new triterpene glycosides from Salacia cochinchinensis were identified. Two compounds, racemiside and alangiplatanoside, demonstrated significant alpha-glucosidase inhibition, offering potential for diabetes management.
Area of Science:
- Natural Products Chemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Salacia cochinchinensis is a plant species with potential medicinal properties.
- Triterpene glycosides are a class of natural compounds known for diverse biological activities.
- Alpha-glucosidase inhibitors are crucial for managing type 2 diabetes by controlling postprandial hyperglycemia.
Purpose of the Study:
- To isolate and characterize new triterpene glycosides from Salacia cochinchinensis.
- To evaluate the alpha-glucosidase inhibitory potential of isolated compounds.
Main Methods:
- Phytochemical investigation of Salacia cochinchinensis using 90% ethanol extract.
- Structure elucidation of isolated compounds employing spectroscopic techniques (MS, IR, 1D and 2D NMR).
- In vitro assessment of alpha-glucosidase inhibitory activity using IC50 values.
Main Results:
- Four new triterpene glycosides, salaciacochinosides A-D (1-4), were isolated and characterized.
- Five known compounds, including 2α,3β,23-trihydroxyurs-12,18-dien-28-oic acid 28-O-β-d-glucopyranoside (5), racemiside (6), alangiplatanoside (7), acantrifoside E (8), and syringin (9), were also identified.
- Compounds 6 and 7 exhibited potent alpha-glucosidase inhibition (IC50 = 0.44 and 0.75 μM, respectively).
- Compounds 1-5 displayed moderate inhibitory activity, while compounds 8 and 9 showed no significant activity.
Conclusions:
- Salacia cochinchinensis is a source of novel triterpene glycosides with alpha-glucosidase inhibitory properties.
- Racemiside and alangiplatanoside are promising candidates for the development of new anti-diabetic agents.
- Further research into the mechanism of action and in vivo efficacy of these compounds is warranted.
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