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Published on: September 25, 2017
Development of Electrocardiographic Left Ventricular Hypertrophy and Resting Heart Rate Over Time: Findings From the
Taku Inoue1,2, Hisatomi Arima2, Yuriko Katsuimata3
1Cardiovascular Medicine, Nambu Hospital, Okinawa, Japan.
Insights
Higher resting heart rate (HR) was linked to a lower risk of developing electrocardiographic left ventricular hypertrophy (ECG-LVH) in men. This study suggests an inverse relationship between resting HR and ECG-LVH development in males.
Area of Science:
- Cardiology
- Clinical Research
- Preventive Medicine
Background:
- Elevated resting heart rate (HR) and electrocardiographic left ventricular hypertrophy (ECG-LVH) are indicators of poor prognosis.
- While elevated HR is a known cardiovascular risk factor, its association with ECG-LVH development is not well-understood.
Purpose of the Study:
- To investigate the relationship between resting heart rate and the incidence of electrocardiographic left ventricular hypertrophy.
- To determine if resting heart rate predicts the development of ECG-LVH in a general population.
Main Methods:
- Prospective cohort study involving 6860 subjects (aged 19-89) without baseline ECG-LVH.
- Follow-up duration of 3.7±1.4 years, with incidence of ECG-LVH recorded.
- Cox regression analysis was used to assess the association between resting HR and ECG-LVH development.
Main Results:
- During follow-up, 484 subjects (7.1%) developed ECG-LVH.
- Each 10 beats/min increase in resting HR was associated with a 22% reduction in ECG-LVH development in men (P < .0001).
- The association between resting HR and ECG-LVH development was not statistically significant in women.
Conclusions:
- Resting heart rate demonstrated a negative association with the development of ECG-LVH in men.
- Findings contrast with the traditional view of elevated resting HR as a cardiovascular risk factor, suggesting a protective role against ECG-LVH in men.
- Further research is needed to elucidate the mechanisms behind this observed inverse relationship.
Abstract:
Both elevated resting heart rate (HR) and electrocardiographic left ventricular hypertrophy (ECG-LVH) are signs of a poor prognosis. Although elevated resting HR is a known risk factor for cardiovascular disease and target organ damage, the association between resting HR and the development of ECG-LVH is unclear. In the present study, 6860 subjects (4203 men, 2657 women, 19-89 years of age) without ECG-LVH at baseline were evaluated and followed for a mean duration of 3.7±1.4 years. During the follow-up period, 484 (7.1%) subjects developed ECG-LVH. Cox regression analysis revealed that each 10 beats/min increase in resting HR was associated with a 22% reduction in the development of ECG-LVH (95% confidence interval: 12%-30%, P < .0001) in men. While an increase in HR tended to be associated with the development of ECG-LVH in women, the relationship was not significant. In contrast to the concept that an elevated resting HR is a cardiovascular risk factor, these findings revealed that resting HR was negatively associated with the development of ECG-LVH in men.
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