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Association of serum growth differentiation factor 15 level with acute ischemic stroke in a Chinese population

Xiaoyu Dong1, Jianfei Nao1

  • 1Department of Neurology, Shengjing Hospital of China Medical University , Shenyang , Liaoning , PR China.

The International Journal of Neuroscience
|August 27, 2019
PubMed

Insights

Serum Growth Differentiation Factor 15 (GDF-15) levels are elevated in acute ischemic stroke (AIS) patients. Higher GDF-15 on day 7 predicts poor outcomes, indicating its prognostic value in stroke patients.

Area of Science:

  • Biochemistry
  • Neurology
  • Cardiovascular Medicine

Background:

  • Growth Differentiation Factor 15 (GDF-15), a member of the TGF-ß family, is linked to cardiovascular diseases, diabetes, and cerebrovascular disease.
  • Elevated GDF-15 concentrations are potential biomarkers for various health conditions.

Purpose of the Study:

  • To investigate the clinical significance of serum GDF-15 levels in Chinese patients following acute ischemic stroke (AIS).
  • To assess the association between GDF-15 levels and stroke severity, and predict patient outcomes.

Main Methods:

  • Compared serum GDF-15 levels between 83 AIS patients and 124 controls at admission.
  • Measured GDF-15 and NIH Stroke Scale scores at admission and day 7 post-stroke.
  • Utilized diffusion-weighted MRI for stroke volume calculation and modified Rankin Scale for 90-day outcome assessment.

Main Results:

  • AIS patients exhibited significantly higher serum GDF-15 levels at admission compared to controls (p < .01).
  • Elevated GDF-15 on day 7 correlated with poorer outcomes (p < .05) and larger stroke volumes (p < .01).
  • Logistic regression revealed GDF-15 as an independent predictor of AIS (admission, p < .01) and poor 90-day outcomes (day 7, p < .05).

Conclusions:

  • Serum GDF-15 at admission is independently associated with AIS in the studied population.
  • Serum GDF-15 on day 7 serves as an independent predictor of 90-day outcomes after AIS.
  • GDF-15 holds potential as a prognostic biomarker for acute ischemic stroke.

Keywords:
Strokegrowth differentiation factor 15 (GDF-15)prognosis

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