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Related Concept Videos

Chronic Pharyngitis01:23

Chronic Pharyngitis

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Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

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COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

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[Chronic lymphocytic leukemia].

Nathalie Jacque1, Véronique Leblond2

  • 1Hôpital Pitié-Salpêtrière, service d'hématologie, 75013 Paris, France.

Presse Medicale (Paris, France : 1983)
|August 27, 2019
PubMed
Summary
This summary is machine-generated.

Chronic lymphocytic leukemia (CLL) is a common adult leukemia. Diagnosis involves blood tests and flow cytometry, with immunochemotherapy as a primary treatment for most patients.

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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
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HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
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HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
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Area of Science:

  • Hematology
  • Oncology

Background:

  • Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia.
  • A significant portion of patients (80%) are asymptomatic at diagnosis, and 30% may never require treatment.
  • Current diagnostic standards rely on blood smear examination and immunophenotyping via flow cytometry.

Purpose of the Study:

  • To outline the diagnostic and therapeutic landscape of chronic lymphocytic leukemia.
  • To discuss current first-line treatment strategies and emerging therapeutic options.
  • To describe follow-up protocols for asymptomatic CLL patients.

Main Methods:

  • Review of diagnostic criteria for CLL, including blood smear analysis and flow cytometry.
  • Analysis of current first-line treatment protocols, primarily immunochemotherapy.
  • Discussion of novel targeted therapies for relapsed CLL.
  • Outline of monitoring strategies for stable, asymptomatic CLL.

Main Results:

  • Immunochemotherapy is the standard first-line treatment for 90% of CLL patients lacking chemo-resistance genetic markers.
  • New targeted therapies are increasingly utilized, particularly for relapsed cases, and represent future treatment alternatives.
  • Asymptomatic patients with stable disease can be managed by general practitioners with regular check-ups.

Conclusions:

  • CLL management involves specific diagnostic methods and established first-line treatments.
  • Emerging targeted therapies offer promising alternatives, especially for refractory disease.
  • Long-term follow-up by general practitioners is feasible for stable, asymptomatic CLL patients.