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Related Concept Videos

Schemas01:42

Schemas

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A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
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[Follicular lymphoma: An update].

Pierre Sujobert1, Gilles Salles2

  • 1Groupement hospitalier Sud, hospices civils de Lyon, service d'hématologie biologique, 69310 Lyon, France; Inserm U1052 CNRS 5286, centre de recherche en cancérologie de Lyon (CRCL), équipe « clinical and experimental models of lymphomagenesis », 69600 Lyon, France; Université de Lyon, université Claude-Bernard Lyon 1, faculté de médecine et de Maïeutique Lyon-Sud-Charles-Mérieux, 69600 Lyon, France.

Presse Medicale (Paris, France : 1983)
|August 27, 2019
PubMed
Summary

Follicular lymphoma, a slow-growing cancer, is manageable with modern treatments like anti-CD20 antibodies. Advances have significantly improved patient life expectancy, now exceeding 15 years.

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Follicular lymphoma is the second most common lymphoma, characterized by slow progression.
  • Diagnosis relies on lymph node biopsy, but patient prognosis is highly variable.
  • Understanding disease mechanisms is crucial for effective therapeutic strategies.

Purpose of the Study:

  • To review current understanding and management of follicular lymphoma.
  • To highlight the impact of novel therapies on patient outcomes.
  • To discuss diagnostic and prognostic factors influencing treatment decisions.

Main Methods:

  • Literature review of follicular lymphoma pathogenesis, diagnosis, and treatment.
  • Analysis of advancements in therapeutic approaches, including anti-CD20 monoclonal antibodies.
  • Discussion of staging techniques like 18-fluorodeoxyglucose positron emission tomography (FDG-PET).

Main Results:

  • Anti-CD20 monoclonal antibodies are now a cornerstone of follicular lymphoma treatment.
  • Therapeutic strategies are individualized, ranging from watchful waiting to combination therapies.
  • Despite common relapses, effective interventions are available, improving median life expectancy.

Conclusions:

  • Significant progress in understanding and treating follicular lymphoma has been achieved.
  • Individualized treatment strategies based on staging and prognostic factors are key.
  • Median life expectancy for follicular lymphoma patients now surpasses 15 years.