Related Experiment Video

Updated: Jan 20, 2026

Author Spotlight: Workflow for Integrating POCUS Data into EHR for Managing Heart Failure Patients
03:47

Author Spotlight: Workflow for Integrating POCUS Data into EHR for Managing Heart Failure Patients

Published on: July 12, 2024

1.1K

Increased Heart Failure Prevalence in Patients with a High Antibody Level Against Periodontal Pathogen

Norio Aoyama1, Keitetsu Kure2, Masato Minabe1

  • 1Division of Periodontology, Department of Oral Interdisciplinary Medicine, Graduate School of Dentistry, Kanagawa Dental University.

International Heart Journal
|August 27, 2019
PubMed

Insights

High antibody levels against the periodontal pathogen Porphyromonas gingivalis were linked to increased heart failure rates. This suggests a connection between periodontal disease and cardiovascular health, specifically heart failure.

Area of Science:

  • Oral Health
  • Cardiovascular Medicine
  • Immunology

Background:

  • A known association exists between cardiovascular disease and periodontitis, but causality remains unproven.
  • Inflammatory responses in periodontitis may link periodontal infections to vascular diseases.
  • Understanding this link is crucial for public health and clinical practice.

Purpose of the Study:

  • To investigate the relationship between antibody levels against periodontal pathogens and cardiovascular disease.
  • To determine if specific periodontal pathogens are associated with increased heart failure prevalence.
  • To explore the correlation between periodontal health and systemic inflammatory markers.

Main Methods:

  • Assessed medical history, blood data, and periodontal conditions in cardiovascular disease patients.
  • Analyzed serum IgG antibody titers against major periodontal pathogens, including Porphyromonas gingivalis.
  • Quantified salivary periodontal bacteria and assessed periodontal parameters like probing pocket depth.

Main Results:

  • Patients with high antibody levels against Porphyromonas gingivalis showed a higher prevalence of heart failure.
  • Increased probing pocket depth and clinical attachment level were observed in the high antibody group.
  • Elevated antibody levels against P. gingivalis correlated with heightened antibodies against other periodontal bacteria.

Conclusions:

  • High antibody levels against Porphyromonas gingivalis are associated with increased heart failure prevalence.
  • Periodontal infection may play a role in the development or exacerbation of cardiovascular conditions.
  • Further research is warranted to elucidate the causal mechanisms linking periodontitis and heart failure.

Keywords:
Cardiovascular diseaseInfectionInflammationPeriodontitis

More Related Videos

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure04:20

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure

Published on: October 1, 2019

6.2K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

2.0K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
768
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.0K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
720
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
273
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
821
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
225