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Related Experiment Video

Updated: Jan 20, 2026

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat
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Metastatic Latency, a Veiled Threat.

Kangsan Kim1,2, Mauricio Marquez-Palencia1,2, Srinivas Malladi1,2

  • 1Department of Pathology, UT Southwestern Medical Center, Dallas, TX, United States.

Frontiers in Immunology
|August 27, 2019
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Summary

Latent metastatic cancer cells can cause relapse years after treatment. Preclinical models offer a framework to target these dormant cells, aiming for cures by eliminating them before they regrow.

Keywords:
dormancyimmune-surveillancelatencymetastasismicroenvironmentminimal residual disease

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Area of Science:

  • Oncology
  • Cancer Biology
  • Immunology

Background:

  • Metastatic relapse occurs months to decades after initial cancer treatment, even with no clinical evidence of disease.
  • Disseminated tumor cells (DTCs) entering reversible cell cycle arrest are implicated in late relapses.
  • Tumor microenvironment interactions support latent DTC survival and immune evasion.

Purpose of the Study:

  • To define and target the latent metastatic phase of tumor progression.
  • To provide a conceptual framework based on preclinical models.
  • To identify therapeutic strategies for eliminating dormant metastatic cells.

Main Methods:

  • Utilized preclinical cancer models to study latent metastatic disease.
  • Investigated the dynamics between disseminated tumor cells and their microenvironment.
  • Explored mechanisms of cancer cell survival and immune evasion in dormancy.

Main Results:

  • Established a conceptual framework for understanding the latent metastatic phase.
  • Highlighted the role of tumor microenvironment in supporting dormant cancer cells.
  • Demonstrated the potential for targeting latent disseminated tumor cells.

Conclusions:

  • Targeting latent metastatic cells before they emerge could lead to long-lasting cures.
  • Identifying patients with latent metastatic cells is crucial for effective intervention.
  • Further research in preclinical models can guide therapeutic development for metastatic relapse.