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Related Experiment Video

Updated: Jan 20, 2026

Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin
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T Cells Control Chemokine Secretion by Keratinocytes.

Tabea Rauschenberger1, Viola Schmitt1, Muhammad Azeem1

  • 1Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.

Frontiers in Immunology
|August 27, 2019
PubMed
Summary

T cells significantly influence skin chemokine production by keratinocytes, impacting inflammatory skin diseases. This interaction involves specific gene regulation critical for understanding skin immunity.

Keywords:
IFNNfatc1T cellschemokinekeratinocyteslichen planus

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Area of Science:

  • Immunology
  • Dermatology
  • Molecular Biology

Background:

  • Lymphocyte infiltration is characteristic of many skin disorders.
  • The communication between lymphocytes and skin cells is crucial for immune responses.

Purpose of the Study:

  • To investigate the molecular mechanisms by which T cells regulate keratinocyte chemokine production.
  • To elucidate the role of T cell-derived factors in modulating skin inflammation.

Main Methods:

  • Co-culture of murine keratinocytes with splenic T cells.
  • Analysis of chemokine synthesis and gene expression.
  • Investigation of NFAT factors and Interferon-gamma (IFN-γ) in T cells.

Main Results:

  • Pre-activated CD8+ T cells induce CXCL9 and CXCL10 in keratinocytes, while suppressing CXCL1, CXCL5, and CCL20.
  • Keratinocytes reduce CCL3 and CCL4 synthesis in T cells.
  • IFN-γ, regulated by NFATc1/NFATc2, is essential for T cell-induced chemokine expression.
  • T cells induce type I IFN-inducible genes in keratinocytes, mirroring patterns in lichen planus.

Conclusions:

  • T cells dynamically control keratinocyte chemokine profiles.
  • NFAT-dependent IFN-γ production by T cells is a key mediator of this interaction.
  • The findings provide molecular insights into T cell-keratinocyte crosstalk in inflammatory skin conditions.