Recent advances in understanding the mechanisms determining longevity
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Updated: Jan 20, 2026

Determining the Mechanical Strength of Ultra-Fine-Grained Metals
Published on: November 22, 2021
Robert Bayersdorf1,2, Björn Schumacher1,2
1Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Cologne, Germany.
Abstract:
The field of aging research has progressed significantly over the past decades. Exogenously and endogenously inflicted molecular damage ranging from genotoxic to organellar damage drives the aging process. Repair mechanisms and compensatory responses counteract the detrimental consequences of the various damage types. Here, we discuss recent progress in understanding cellular mechanisms and interconnections between signaling pathways that control longevity. We summarize cell-autonomous and non-cell-autonomous mechanisms that impact the cellular and organismal aging process.
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