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Updated: Oct 9, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
"Tram-line" Calcifications in Granulomatosis with Polyangiitis
David Livingston1, Celin Rajan2, J Mark McKinney1
1Department of Radiology, Mayo Clinic Jacksonville, Florida United States.
Abstract:
Nephrocalcinosis consists of deposition of calcium in the renal parenchyma. Renal cortical calcification is a rare entity in comparison to calcium deposits in the medulla and is seen only in a handful of pathologies with corresponding characteristic patterns on imaging. Thin linear calcifications may get deposited in the peripheral renal cortex suggestive of cortical necrosis due to a vascular insult (vasculitis), and rarely due to glomerulonephritis. This pattern of calcification has also been referred to as the "tramline" or "railroad track" sign.
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