Related Experiment Video
Updated: Jan 20, 2026
09:13
Hydroponics: A Versatile System to Study Nutrient Allocation and Plant Responses to Nutrient Availability and Exposure to Toxic Elements
Published on: July 13, 2016
32.6K
Duodenal nutrient exposure contributes to enhancing gastric accommodation
Florencia Carbone1, Sofie Verschueren1, Alessandra Rotondo1
1Translational Research Centre for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.
Neurogastroenterology and Motility
|August 27, 2019
Summary
Duodenal nutrient exposure enhances gastric accommodation. Blocking nutrient passage to the duodenum reduces accommodation and increases fullness and nausea, impacting meal-induced satiation.
Area of Science:
- Gastroenterology
- Digestive Physiology
Background:
- Gastric accommodation is a reflex allowing stomach relaxation to hold ingested food.
- The precise mechanisms controlling gastric accommodation remain incompletely understood.
- This study investigates the role of duodenal nutrient sensing in gastric accommodation and satiation.
Purpose of the Study:
- To determine the contribution of duodenal nutrient exposure to gastric accommodation.
- To assess the impact of duodenal nutrient exposure on meal-induced satiation.
- To investigate the relationship between pyloric function and epigastric symptom perception.
Main Methods:
- Intragastric pressure (IGP) was measured in 11 healthy subjects during nutrient drink infusion.
- Pyloric balloon obstruction was used to prevent duodenal nutrient passage.
- Subjects reported satiation and epigastric symptoms using Likert scales and visual analogue scales.
Main Results:
- Pyloric obstruction significantly reduced IGP drop and area under the curve compared to control.
- Nutrient tolerance was decreased with pyloric obstruction (787.9 mL vs 970.9 mL).
- Pyloric obstruction exacerbated symptoms of bloating, fullness, and nausea.
Conclusions:
- Duodenal nutrient exposure is crucial for enhancing gastric accommodation.
- Inhibiting duodenal nutrient passage impairs gastric accommodation.
- Blocking duodenal nutrient flow increases satiation, bloating, nausea, and fullness.
Related Concept Videos
01:19Absorption of Nutrients
2.8K
Absorption refers to taking dietary nutrients from the intestinal lumen for transportation throughout the body. After digestion in the small intestine, carbohydrates, proteins, and fats are broken down into simpler forms. These essential macronutrients and other vital substances, such as vitamins, minerals, and water, are then prepared for absorption into the bloodstream.
Enterocytes, which are specialized polar epithelial cells, line the mucosa of the small intestinal walls. These cells...
Enterocytes, which are specialized polar epithelial cells, line the mucosa of the small intestinal walls. These cells...
2.8K
01:16Gastric Motility
2.9K
Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
2.9K
01:23Binet's Contribution to Measures of Intelligence
1.7K
Alfred Binet, along with his student Théophile Simon, was tasked by the French Ministry of Education in 1904 to create a method for identifying students who struggled to learn through conventional classroom instruction. This initiative aimed to address overcrowding by placing such students in specialized schools. Binet and Simon developed an intelligence test comprising 30 tasks, ranging from simple commands, like touching one's nose or ear, to more complex tasks, such as drawing...
1.7K
01:16Gastric Emptying
3.4K
Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
3.4K
01:23Wechsler's Contribution to Measures of Intelligence
2.0K
David Wechsler, a psychologist who worked with World War I veterans, developed a significant IQ test in 1939 called the Wechsler-Bellevue Intelligence Scale. This test was innovative because it combined several subtests that measured both verbal and nonverbal skills, reflecting Wechsler's belief that intelligence is a global capacity involving purposeful action, rational thinking, and effective interaction with the environment. This test later evolved into the Wechsler Adult Intelligence...
2.0K
01:26Gastric Phase of Digestion
3.1K
The gastric phase of digestion begins as soon as food enters the stomach. The incoming food bolus triggers neural and hormonal mechanisms, which last approximately 3 to 4 hours. During this phase, the stomach undergoes significant changes to prepare the food for further digestion and absorption.
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
3.1K