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Antivenin-associated serum sickness in a dog
Benjamin M Lee1, Kristin M Zersen1, Jennifer R Schissler1
1Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523.
Summary
A dog developed serum sickness after receiving a novel antivenin. This case highlights the risk of delayed hypersensitivity reactions to antivenom treatments, even with a single dose.
Area of Science:
- Veterinary Medicine
- Immunology
- Toxicology
Background:
- Antivenom therapy is crucial for treating venomous snakebites.
- Novel antivenom products require thorough safety evaluations.
Observation:
- A dog exhibited delayed hypersensitivity reactions, including swelling and vasculitis, one and two weeks post-antivenin administration.
- Clinical signs included edema, urticaria, gastrointestinal issues, and vasculitis.
Findings:
- This case represents the first documented instance of serum sickness in a dog following a single dose of a novel antivenin crotalidae polyvalent.
- Recurrence of hypersensitivity occurred one week after the initial episode.
Implications:
- This case underscores the potential for delayed hypersensitivity reactions to novel antivenom plasma products.
- Careful consideration of risk-benefit and prolonged monitoring are essential when administering antivenins.
- Further research into the immunogenicity of new antivenom formulations is warranted.
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