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Updated: Jan 20, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

13.0K

What therapies are on the horizon for HER2 positive breast cancer?

Giulia Viale1,2, Stefania Morganti1,2, Emanuela Ferraro1,2

  • 1Division of Early Drug Development for Innovative Therapy, IEO, European Institute of Oncology IRCCS , Milan , Italy.

Expert Review of Anticancer Therapy
|August 27, 2019
PubMed

Insights

New drugs and combination strategies are being developed to combat HER2-positive metastatic breast cancer, aiming to overcome resistance and improve survival for patients with this deadly disease.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • HER2-positive metastatic breast cancer (MBC) has improved survival with anti-HER2 agents, but resistance remains a significant challenge.
  • Developing novel therapies and combination strategies is crucial for overcoming treatment resistance in HER2-positive MBC.

Purpose of the Study:

  • To review emerging drugs and therapeutic combinations for HER2-positive MBC.
  • To explore strategies for overcoming resistance to HER2-directed therapies.

Main Methods:

  • Literature review of drugs in development for HER2-positive MBC.
  • Analysis of combination strategies including immunotherapy, PI3K/mTOR inhibitors, and CDK4/6 inhibitors.

Main Results:

  • The review covers antibody-drug conjugates, monoclonal antibodies, bispecific antibodies, and novel tyrosine kinase inhibitors.
  • Combination therapies show promise in overcoming resistance mechanisms.

Conclusions:

  • Novel agents and combination strategies are essential for improving outcomes in HER2-positive MBC.
  • Predictive biomarkers are needed to guide treatment sequencing and reduce financial toxicity.
Keywords:
DS-8201aHER2 positive advanced breast cancerantibody drug conjugatesimmunotherapymargetuximabnew drug developmenttyrosine kinase inhibitors

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