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Relationships Between Early Neonatal Nutrition and Neurodevelopment at School Age in Children Born Very Preterm

Anna C Tottman1, Jane M Alsweiler1,2, Frank H Bloomfield1

  • 1Liggins Institute.

Journal of Pediatric Gastroenterology and Nutrition
|August 27, 2019
PubMed

Insights

Higher early protein intake in preterm infants did not affect overall neurodevelopment or growth at seven years. However, increased parenteral protein was linked to a higher risk of cerebral palsy, warranting further research into motor development.

Area of Science:

  • Neonatal nutrition
  • Pediatric neurodevelopment
  • Infant growth

Background:

  • Optimizing nutrition for very preterm infants is crucial for development.
  • Previous protocols focused on fluid volume, potentially limiting nutrient delivery.
  • A new protocol aimed to increase early protein while reducing fluid.

Purpose of the Study:

  • To evaluate the impact of a new nutrition protocol on neurodevelopment and growth in childhood.
  • To assess if increased early protein intake affects outcomes in very preterm infants.

Main Methods:

  • Retrospective observational cohort study of infants born before 30 weeks' gestation.
  • Compared neurodevelopmental impairment at 7 years between infants exposed to old and new nutrition protocols.
  • Used generalized linear regression, adjusting for sex and birth weight z-score.

Main Results:

  • No significant difference in neurodevelopmental impairment (41% vs 45%) or cerebral palsy incidence between groups.
  • Growth and body composition were similar between groups.
  • Higher early parenteral protein intake (1g/kg) was associated with increased odds of cerebral palsy (AOR 1.27).

Conclusions:

  • Increased early protein and reduced fluid intake did not alter overall neurodevelopment or growth at 7 years.
  • Higher early parenteral protein intake may be associated with an increased risk of cerebral palsy.
  • Further investigation into the effects of early parenteral protein on motor development is recommended.
Abstract

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