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High A20 expression negatively impacts survival in patients with breast cancer

Chang Ik Yoon1, Sung Gwe Ahn2, Soong June Bae2

  • 1Department of Surgery, St Mary's Hospital, Catholic University College of Medicine, Seoul, Korea.

Plos One
|August 27, 2019
PubMed
Abstract

Insights

High A20 protein expression indicates poor survival outcomes in breast cancer patients, particularly those with aggressive subtypes like HER2-positive and triple-negative breast cancer (TNBC). This suggests A20 may be a potential therapeutic target for aggressive breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • A20 protein regulates inflammation and immunity through ubiquitin-editing activities.
  • Previous research linked A20 to tumor metastasis in basal-like breast cancer via SNAIL1 modification.
  • This study examines the prognostic significance of A20 expression in diverse breast cancer patient cohorts.

Purpose of the Study:

  • To investigate the association between A20 protein expression levels and patient survival outcomes in breast cancer.
  • To determine if A20 expression serves as an independent prognostic marker for recurrence-free survival (RFS) and overall survival (OS).
  • To evaluate the prognostic impact of A20 in specific aggressive breast cancer subtypes, including HER2-positive and triple-negative breast cancer (TNBC).

Main Methods:

  • Retrospective analysis of tumor samples from 442 breast cancer patients.
  • Immunohistochemistry (IHC) using an A20-specific antibody to assess protein expression.
  • Statistical analysis of survival data, including recurrence-free survival (RFS) and overall survival (OS), with multivariate analysis.

Main Results:

  • High A20 expression correlated with advanced disease stage and younger patient age.
  • Significantly inferior RFS and OS were observed in patients with high A20 expression (P<0.001 for both).
  • A20 was identified as an independent prognostic marker for RFS (HR=2.324) and OS (HR=2.629).
  • High A20 levels were associated with poorer OS in HER2-positive and TNBC subtypes.

Conclusions:

  • A20 protein expression is a significant poor prognostic marker in breast cancer.
  • The negative prognostic impact of A20 is particularly pronounced in aggressive subtypes like HER2-positive and TNBC.
  • A20 represents a potential therapeutic target for patients diagnosed with aggressive forms of breast cancer.

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