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Updated: Jan 20, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Staged transcatheter closure for atrial septal defect and patent ductus arteriosus: a case report
Yusuke Soma1, Yasuyuki Shiraishi1, Hideaki Kanazawa1
1Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo, Japan.
Insights
A staged transcatheter closure, first patent ductus arteriosus (PDA) then atrial septal defect (ASD), is a safe strategy for adults with combined cardiac defects, avoiding complications from simultaneous procedures.
Area of Science:
- Cardiology
- Congenital Heart Disease
- Interventional Cardiology
Background:
- Atrial septal defect (ASD) and patent ductus arteriosus (PDA) are common congenital heart diseases.
- The combination of ASD and PDA is rare, with controversial therapeutic strategies.
- Adult patients present unique challenges for surgical intervention.
Purpose of the Study:
- To present a successful treatment strategy for a rare combination of congenital heart defects in an adult.
- To evaluate the safety and efficacy of a staged transcatheter closure approach.
- To provide insights into the management of combined ASD and PDA in adults.
Main Methods:
- A two-stage transcatheter closure was performed.
- Patent ductus arteriosus (PDA) closure preceded atrial septal defect (ASD) closure.
- This staged approach aimed to prevent serious complications.
Main Results:
- The patient with combined ASD and PDA achieved a successful outcome.
- The two-stage transcatheter closure was safely attained.
- The staged strategy mitigated risks associated with simultaneous closure.
Conclusions:
- Transcatheter closure is a viable alternative to surgery for adults with combined ASD and PDA.
- A staged closure strategy is recommended to prevent complications like thrombocytopenia and hemolysis.
- The staged approach optimizes antiplatelet therapy and hemodynamic management.
Background:
Atrial septal defect (ASD) and patent ductus arteriosus (PDA) are both common congenital heart diseases, but the combination of these two cardiac defects is extremely rare, and the therapeutic strategy is controversial.
Case Summary:
We treated an adult patient with combined ASD and PDA, and safely attained a successful outcome with two-stage transcatheter closure, which is PDA closure preceding ASD closure, to prevent serious complications.
Discussion:
Transcatheter closure of one of the defects is now widely accepted as an alternative to surgical closure. In addition, adults with both ASD and PDA are better suited for transcatheter closure than surgical closure. One of the reasons is the difficulty to ligate the ductus arteriosus of an adult patient due to its friability and calcification. Meanwhile, simultaneous combined transcatheter closure of ASD and PDA can result in serious complications, such as thrombocytopenia and haemolysis, whose mechanism is considered to be the destruction of platelets and red blood cells by the residual shunt through implanted devices. Additionally, antiplatelet therapy that prevents device-related thrombus formation after ASD closure can possibly exacerbate thrombocytopenia and haemolysis. Therefore, the staged strategy is reasonable from the perspectives of antiplatelet therapy and haemodynamic changes.
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